For Patients What is Z-Lig?

Z-Lig is new option for revision and multiligament ACL reconstruction surgeries. It is safe and effective, and is used in a standard surgical approach. Z-Lig addresses the risk of tissue rejection and is designed to create better results for the patient.

The ACL (the anterior cruciate ligament) lives inside of your knee joint. When the ACL is torn, it affects function of the knee, limits movement and causes pain.

How Z-Lig works: 

1

We take the safe tissues ...

Animal tissue is harvested from ISO certified facilities with the strongest attention to safety and quality.

2

... and strip them of antigens that cause rejection.

Tissue is chemically processed. Alpha-galactosidase enzyme is used to remove the key carbohydrate responsible for acute rejection.

3

After implementation, the Z-Lig, regenerates into the patient's own tissue.

Z-Lig is humanized, through our patented process which produces human immune system compatible tissue.

4

Surgeons use Z-Lig like any other graft.

Z-Lig is ready to use, and has been designed to require no changes in surgical technique.

5

This is designed to create better results for patients.

After surgery, the tissue remodels itself over time to be indistinguishable from the patient's own tissue.

Real patient story

ACL reconstruction for pro-skier using Z-Lig, a natural alternative tissue - 11 years post op

In 2002, Canadian Pro Skier Rick Lewon had his right ACL reconstructed by Dr. Kevin Stone, using a Z-Lig replacement device a natural alternative tissue engineered from porcine tissue. Dr. Stone's treatment was a medical breakthrough and the first non-human biologic method for ACL reconstruction of the knee. After this surgery, Lewon went on to win numerous Canadian Downhill Masters titles. 11 years later, his Xenograft is still going strong and is doing a lot better than the ACL reconstruction he had done on his left leg, which used his own hamstring. Lewon says he is hoping to one day get the Z-Lig on on that knee too.

Z-Lig is approved for use in select indications in the European Union

ACL reconstruction using Z-Lig, a natural alternative tissue | Patient Story - 13 years post op

One of the first patients in the world to have a xenograft ligament replacement using porcine tissue, Canadian Pro Skier Rick Lewon had his right ACL reconstructed by Dr. Kevin Stone. After this surgery, Lewon went on to win numerous Canadian Downhill Masters titles. Now 13 years later the Z-Lig, is still going strong and is doing a lot better than the ACL reconstruction he had done on his left leg, which used his own hamstring.

Z-Lig is approved for use in select indications in the European Union

ACL reconstruction using Z-Lig, a natural tissue alternative | Patient Story - 9 years post op

Mike had both of his ACLs replaced at different times with different procedures. He is able to compare what it's like to have his ACLs rebuilt with the Z-Lig replacement device vs an autograft (using his own tissue). His first ACL replacement was in his left knee and was done using tissue harvested from his own patella tendon. 

Z-Lig is approved for use in select indications in the European Union

ACL reconstruction using Z-Lig, a natural tissue alternative | Patient Story- 9 years post op

Marlise tore her Anterior Cruciate Ligament (ACL) in a ski accident. She had an ACL reconstruction using a Z-Lig replacement device, a a natural tissue alternative engineered from porcine tissue (rather than relying on scarce human donor tissue or using tissue from her own body such as a patella tendon.) Less than a year after surgery she reported that her knee had full range of motion, no pain and was totally back to normal. She says "It's now 9 years later and I feel great. I ski, I run, I hike, I can do anything I want."

Z-Lig is approved for use in select indications in the European Union

World Champion Ski Racer and Z-Lig Patient for Knee Surgery

Ski Racing in 2003, RL ruptured his right knee ACL. In the previous decade, he had torn his left ACL and had it surgically reconstructed with his own tissue or autograft. RL was enrolled in the pilot FDA clinical trial of the Z-Lig BTB device (an investigational ACL reconstruction device) developed by Aperion Biologics, Inc. Twelve years post ACL reconstruction, this device continues to perform successfully. RL continues as a professional ski instructor and racer and has averaged over 100 ski days a year. In addition, RL has won the Canadian Masters Ski Championship three times with the Z-Lig device.

Z-Lig is approved for use in select indications in the European Union

ACL reconstruction using Z-Lig, a natural tissue alternative | Patient Story - 12 years post op

Our patient Mike ruptured his right ACL while Limbo dancing at a wedding. He had it repaired using the Z-Lig ligament replacement device engineered from porcine tissue. Previously, Mike had ruptured his left ACL and had it repaired using an autograft from his own patella tendon. "The experiences could not have been more different" he says. Unlike the autograft, the Z-Lig procedure and the recovery was minimal. "In fact, I was a bit worried because my knee was so stable and so pain free that I thought I might damage the knee somehow because it felt so good so soon!" He now does all the things he does before the surgery, league basketball, coaches baseball, plays with his dog. In fact, he says "because of the physical therapy and the activities I went though, I think it's better than it was before the injury"

Z-Lig is approved for use in select indications in the European Union

ACL reconstruction using Z-Lig, a natural tissue alternative | Patient Story - 13 years post op

Marlise tore her Anterior Cruciate Ligament (ACL) in a ski accident. She had an ACL reconstruction using a Z-Lig replacement device, a a natural tissue alternative engineered from porcine tissue (rather than relying on scarce human donor tissue or using tissue from her own body such as a patella tendon.) Less than a year after surgery she reported that her knee had full range of motion, no pain and was totally back to normal. She says "It's now 9 years later and I feel great. I ski, I run, I hike, I can do anything I want."

Z-Lig is approved for use in select indications in the European Union

ACL reconstruction using Z-Lig, a natural tissue alternative | Patient Story - 13 years post op

Z-Lig is approved for use in select indications in the European Union

Ask your doctor if Z-Lig is the right solution for you.